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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Phorbol 12-myristate 13-acetate, Apicularen A
Phytochemical Name Phorbol 12-myristate 13-acetate (PubChem CID: 27924 )
Anticancer drug Name Apicularen A (PubChem CID: 10718000 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 511
Ref_1
Pair Name Phorbol 12-myristate 13-acetate, Apicularen A
Disease Info [ICD-11: 2C77.Z] Cervical cancer Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Up-regulation Expression CASP3 hsa836
Up-regulation Expression PARP1 hsa142
Down-regulation Expression PRKCA hsa5578
Down-regulation Expression TUBA1B hsa10376
Down-regulation Expression TUBB3 hsa10381
In Vitro Model HeLa Human papillomavirus-related cervical adenocarcinoma Homo sapiens (Human) CVCL_0030
Result These results suggest that the synergy between PMA and apicularen A is involved by PKCα activation and microtubule disruption, and that may inform the development of novel approaches to treat cancer.
03. Reference
No. Title Href
1 PMA synergistically enhances apicularen A-induced cytotoxicity by disrupting microtubule networks in HeLa cells. BMC Cancer. 2014 Jan 22;14:36. doi: 10.1186/1471-2407-14-36. Click
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